Organogenesis in Development, Vol. 90

Understanding organogenesis is central to current efforts to direct stem cell differentiation and function in the context of a complex organ. Defects in organogenesis are often the major manifestations of human genetic disease syndromes. This volume describes the development of 10 major organ systems, reviewed by experts in each, to provide an up-to-date overview for researchers within and outside the field, students, teachers and clinicians.

• Summarizes the key morphological and cellular events
• Emphasizes up-to-date research relating to molecular control mechanisms
• Draws on a range of model vertebrates and contemporary experimental approaches, including lessons learnt from human developmental disease
• Distils common themes and differences for comparative studies
• Highlights key remaining questions and sets the agenda for future research

Organogenesis―the development of organs in the embryo―requires groups of cells to co-ordinate their differentiation, replication, movement, position and activities, in order to achieve a specialized function in the body. Accurate reading of the genetic code, intricate programs of molecular signaling within and between cells, and impeccable logistical timing are critical elements that allow each organ to be built successfully.

Understanding organogenesis is central to current efforts to direct stem cell differentiation and function in the context of a complex organ. Defects in organogenesis are often the major manifestations of human genetic disease syndromes. This volume describes the development of 10 major organ systems, reviewed by experts in each, to provide an up-to-date overview for researchers within and outside the field, students, teachers and clinicians.

Key features:

• Summarizes the key morphological and cellular events
• Emphasizes up-to-date research relating to molecular control mechanisms
• Draws on a range of model vertebrates and contemporary experimental approaches, including lessons learnt from human developmental disease
• Distils common themes and differences for comparative studies
• Highlights key remaining questions and sets the agenda for future research