A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. The authoritative contributions cover the major aspects of these receptors, describing the relationships between physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.

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In The P2 Nucleotide Receptors, leading researchers from major laboratories around the world summarize our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. Their authoritative contributions cover the major aspects of these receptors, describing the relationships between the physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.

The critical survey and synthesis offered by The P2 Nucleotide Receptors lays a strong foundation for future work on P2 receptors-some no doubt yet to be cloned-as well as for establishing conclusively the identity of the cloned P2 receptor subtype(s) involved in the varied physiologic effects of extracellular nucleotides. With this broad coverage, the book immediately becomes today's single best source for understanding the major issues and future directions of P2 receptor research.

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