The primary objective of day-to-day ongoing researches to optimize healing and the biggest challenges till date that the researchers are facing the development of a regenerative biomaterial with a potentially regulate inflammation and accelerate wound healing.Platelet concentrate have travelled a long way from introduction of platelet concentrate as a source of blood proteins enriched with growth factors to introduction of newer generation of platelet concentrate such as A-PRF, i-PRF, T-PRF, CGF, ALB.-PRF as its counterparts which are proposed to be much efficient then its predecessor in terms of biological efficacy and its method of preparation.PRF have proved to be an advantageous technique that have provided optimal results in medical and dental surgeries and have also proved its efficacy in numerous research interventions.

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