Parameter Advising for Multiple Sequence Alignment

Language: English

Published by Springer International Publishing Jan 2018, 2018

3319649175 / 9783319649177

Series: Book 13 of 21 - Computational Biology

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -This book develops a new approach called parameter advising for finding a parameter setting for a sequence aligner that yields a quality alignment of a given set of input sequences. In this framework, a parameter advisor is a procedure that automatically chooses a parameter setting for the input, and has two main ingredients: (a) the set of parameter choices considered by the advisor, and (b) an estimator of alignment accuracy used to rank alignments produced by the aligner. On coupling a parameter advisor with an aligner, once the advisor is trained in a learning phase, the user simply inputs sequences to align, and receives an output alignment from the aligner, where the advisor has automatically selected the parameter setting. The chapters first lay out the foundations of parameter advising, and then cover applications and extensions of advising. The content - examines formulations of parameter advising and their computational complexity, - develops methods for learning good accuracy estimators, - presents approximation algorithms for finding good sets of parameter choices, and - assesses software implementations of advising that perform well on real biological data. Also explored are applications of parameter advising to - adaptive local realignment, where advising is performed on local regions of the sequences to automatically adapt to varying mutation rates, and - ensemble alignment, where advising is applied to an ensemble of aligners to effectively yield a new aligner of higher quality than the individual aligners in the ensemble. The book concludes by offering future directions in advising research. 168 pp. Englisch.

Seller Inventory # 9783319649177

Title
Parameter Advising for Multiple Sequence Alignment
Author
John Kececioglu
Publisher
Springer International Publishing Jan 2018
Publication year
2018
Condition
Neu
Binding
Buch
Language
English
ISBN 10
3319649175
ISBN 13
9783319649177
Item weight
424 grams
Dimensions
241x160x15 mm
Series
Book 13 of 21: Computational Biology

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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BuchWeltWeit Ludwig Meier e.K.

Germany