Pathogenicity Islands and the Evolution of Pathogenic Microbes

J. B. Kaper

ISBN 10: 3540426817 / ISBN 13: 9783540426813

Published by Springer Berlin Heidelberg Mrz 2002, 2002

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements. 252 pp. Englisch.

Seller Inventory # 9783540426813

Bibliographic Details

• Title: Pathogenicity Islands and the Evolution of Pathogenic Microbes
• Publisher: Springer Berlin Heidelberg Mrz 2002
• Publication Date: 2002
• Language: English
• ISBN 10: 3540426817
• ISBN 13: 9783540426813
• Binding: Buch
• Condition: Neu
• Dimensions: 241W x 160H x 19D millimeters 241 millimeters width by 160 millimeters height by 19 millimeters depth
• Weight: 547 grams

About this title

Synopsis

It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.

Review

From the reviews:

"In addition to classic mutational events, a highly successful strategy of generating genetic diversity in bacteria is the acquisition of genomic islands. ... This compendium ... features an international assembly of authors including W. Arber (Basel) giving a lucid introduction into the evolution of prokaryotic genomes. The two-volume work provides a comprehensive overview of the current state of knowledge on PAIs and other mobile virulence determinants in bacterial as well as fungal pathogens of humans and plants." (Susanne Rohrer, BioWorld, Issue 6, 2002)