Pathophysiological Aspects of Proteases in Cancer

Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development.

Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.

• Gives insight into the spectrum of proteases, protease inhibitors, and protease interactors involved at the cellular and molecular level in cancer development
• Gives a comprehensive overview of the role of proteases in modulating cellular metabolism and chemoresistance to better understand how proteases play in early to the end point in cancer development and metastasis
• Provides a multidisciplinary approach demonstrating the biochemical and signal transduction mechanisms associated with dysregulation of proteases, leading to the manifestation of various diseases
• Highlights the roles and regulation of different types of proteases, as well as their synthetic and endogenous inhibitors
• Bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry

Dr. Sajal Chakraborti, PhD, DSc is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did post-doctoral research at the Johns Hopkins Medical Institution, Baltimore; New York Medical College, New York; the University of Utah Health Sciences Center, Salt Lake City, Utah; and the University of Florida, Gainesville, Florida. He has over 40 years teaching and independent research experience in biochemistry, molecular physiology and cell biology. He has published over 110 original research articles, dozens of review articles and book chapters, and also edited fifteen books.

Dr. Srijit Das is currently Professor of Anatomy at the Sultan Quaboos University in Oman. He has decades teaching experience in Anatomy including Embryology, Histology, Gross Anatomy, Neuroanatomy, Radiological Anatomy, Clinical Anatomy, and Surface Anatomy. He is member of World Association of Medical Editors. He published 500 articles in world-renowned journals, published 5 books and is editorial board member of numerous globally respected journals.

Dr. Cheorl-Ho Kim is Professor and Chair of the Department of Biological Sciences, College of Science, Sungkyunkwan University in South Korea. He is also Professor at the Samsung Advanced Institute of Health Science and Technology (SAIHST), South Korea. Dr. Kim obtained his MS and PhD from the University of Tokyo, Japan. Prior academic appointments include Genome Program Head, Korea Research Institute of Bioscience and Biotechnology, and Chairman of the Department of Biochemistry and Molecular Biology, Dongguk University, South Korea. Dr. Kim’s research interests include neurological health, neuroinflammation, oncogenesis, and cancer metastasis.