Pathway Analysis and Optimization in Metabolic Engineering

This book introduces researchers and advanced students in biology and engineering to methods of optimizing biochemical systems of biotechnological relevance. It examines the development of strategies for manipulating metabolic pathways, demonstrates the need for effective systems models, and discusses their design and analysis, while placing special emphasis on optimization. The authors propose power-law models and methods of Biochemical Systems Theory toward these ends. All concepts are derived from first principles, and the text is richly illustrated with numerous graphs and examples throughout.

This book introduces researchers and advanced students in biol ogy and engineering to methods of optimizing biochemical systems of biotechnological relevance. It examines the development of strategies for manipulating metabolic pathways, demonstrates the need for effective systems models, and discusses their design and analysis, while placing special emphasis on optimization. All concepts are derived from first principles, and the text is illustrated with graphs and examples throughout. Other special features include introductions to models of biochemical systems; a review of basic methods of model design and analysis; concepts of optimization; and detailed case studies.