Patterns and algorithms in high-throughput sequencing count data

Language: English

Published by Scholars' Press Jan 2017, 2017

3659846228 / 9783659846229

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -Proteins interacting with the genome, such as histones and transcription factors, play a major role in the regulation of gene expression. Experimental techniques such as ChIP-seq provide a new type of digital sequences that quantify the presence of a protein along the genome. These are count signals: sequences as long as the genetic code, but with the natural numbers as an alphabet. The computational analysis of these sequences is challenging, as the biological patterns are complex and the datasets are large. This thesis presents 3 efficient algorithms for pattern detection problems in count signals. The first infers the genomic locations of positioned nucleosomes by using an appropriate wavelet and by integrating measurements from multiple ChIP-seq experiments. The second characterizes the regulatory processes acting on the chromatin and is based on an accurate probabilistic model for read counts. The third detects transcription factor binding sites from ChIP-exo data by simultaneously modelling the sequence and the read counts associated to a binding event. Overall, the thesis presents a general computational framework that is likely to be important for future challenges. 140 pp. Englisch.

Seller Inventory # 9783659846229

Title
Patterns and algorithms in high-throughput sequencing count data
Author
Alessandro Mammana
Publisher
Scholars' Press Jan 2017
Publication year
2017
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3659846228
ISBN 13
9783659846229
Item weight
227 grams
Dimensions
220x150x9 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

Shipping rates from Germany to U.S.A.

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BuchWeltWeit Ludwig Meier e.K.

Germany