This book constitutes the refereed proceedings of the 10th International Workshop on Perinatal, Preterm and Paediatric Image Analysis, PIPPI 2025, held in conjunction with the 28th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2025, in Daejeon, South Korea, on September 27, 2025.

The 18 full papers were carefully reviewed and selected from 22 submissions. They were categorized under the following topical sections:

Fetal Brain MRI: Reconstruction, Segmentation, and Development
LLM and Functional Imaging in Fetal and Placental MRI
Neonatal and Pediatric Imaging

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