Peroxynitrite Detection in Biological Media: Challenges and Advances

Peroxynitrite is a powerful oxidiser which can damage a wide array of molecules within cells, including DNA and proteins, leading to apoptosis, inflammation or cancer. Peroxynitrite detection and quantification provides critical information in understanding its biological implications. Attempts to investigate the behavior of peroxynitrite in vivo and in vitro have been hampered by the difficulty in detecting this highly reactive oxygen species. This book presents the current state of the art in this research field with contributions from scientific leaders in the field. The chapters make clear the associated challenges and development for selective and sensitive detection of peroxynitrite.

This book is a timely addition to the literature, as the first in the field, dedicated to detecting this molecule in vivo. It will be welcomed by the community particularly medicinal and analytical chemists, developers of sensors and probes and analytical equipment manufacturers.

Dr. Serban Peteu's research interest is in biosensors, where he has advanced methods to detect metal ions or monitor nitro-oxidative stress in biological fluids. Both electrochemical and optochemical sensing have been investigated, furthermore the response being enhanced via hybrid organic-inorganic nano-architectures. Present work involves nanowire based bio-catalytic interfaces for electrochemical and field-effect sensors. Projects include: semiconductor based lancet type biosensors, electroactive polymers soft actuators, bioreactors designed and fabricated for vaccine research and for water remediation, other equipment and devices to improve the quality of life.

Sabine Szunerits is Full Professor of Chemistry at University of Lille. Her current research interests are in the area of materials science with emphasis on the development of novel nanostructures and approaches for biomedical applications as well as sensing related issues. She is co-author of more than 320 research publications, wrote 24 book chapters and has 7 patents. In 2018, she was awarded with the CNRS Silver Medal for her contribution in the fields of sensing and nanomedicine.