Title: Pharmaceutical Formulation Development Of Peptides And Proteins 2Ed (Hb 2013)
Publisher: CRC Press
Publication Date: 2012
Language: English
ISBN 10: 1439853886
ISBN 13: 9781439853887
Binding: Hardcover
Edition: 2nd Edition
Condition: New

About this title

Synopsis

The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products.

Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product.

Providing integrated solutions, this book discusses:

The synthesis of peptides and the biotechnological production of proteins through recombinant DNA technology
The physicochemical characteristics and stability of peptides and proteins
The formulation of proteins as suspensions, solutions, and (mostly freeze-dried) solids
The opportunities and challenges of non-parenteral delivery of peptides and proteins
Risk factors, specifically the development of an unwanted immune response
A simulation approach to describe the fate of peptides and proteins upon administration to a biological system
The documentation required to register a protein-based drug

Scientists in the pharmaceutical industry and academia as well as postgraduate students in pharmaceutical science will find this a valuable resource.

About the Author

Lars Rovgaard is Principal Scientist for NovoNordisk A/S and a Professor at Copenhagen University, Denmark.

Sven Frokjaer is Dean of the Pharmaceutical Sciences Faculty at the University of Copenhagen Denmark. Marco van de Weert is an Associate Professor of Pharmaceutics and Analytical Chemistry at the University of Copenhagen.

"About this title" may belong to another edition of this title.

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