Synopsis
The fourth edition of a bestselling text, this book covers the use of statistics in pharmaceutical research and clinical evaluation. It includes a disk with special prograns to aid in problem analysis. The coverage progresses from basic definitions and concepts, data graphics, and probability through ANOVA, factorial designs, and optimization techniques. The discussion and examples have been expanded to include GMPs, validation, and quality control, as well as procedures and analyses in bioequivalence studies. The text presents fresh material on concept conformity and release targets and describes linear regression and correlation, the analysis of variance, and crossover designs.
Review
...The book is well written, and has extensive examples and illustrations....The authors have done an excellent job of linking the various statistical applications to research problems in the pharmaceutical industry.
-Journal of Mathematical Psychology
...the 4th edition is even more comprehensive than previous editions....
...We really don't know any author to whom the entire community of pharmaceutical scientists and pharmacy can be so grateful as Bolton. Vastly knowledgeable in every aspect of the subject, he is able to inject vitality into the work, and with the added authorship in the person of Charles Bolton give us a work that will engage and reward everyone involved in pharmaceutical research and clinical evaluation.
-Current Engineering Practice
...all of these chapters are well written, presenting the material in an easy to understand manner.
-Steve Mitchell, Imperial College of London, London, UK
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