Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. As this title is the only comprehensive book on this topic, it is a useful resource for oncology trainees or specialists interested in understanding cancer drug development. Editor(s): Eisenhauer, Elizabeth A.; Twelves, Christopher; Buyse, Marc. Num Pages: 368 pages, With 24 illustrations. BIC Classification: MJCL; MJF; MMG. Category: (G) General (US: Trade). Dimension: 234 x 156 x 16. Weight in Grams: 522. . 2015. Second. paperback. . . . . Books ship from the US and Ireland.

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Bibliographic Details

Title: Phase I Cancer Clinical Trials: A Practical Guide
Publisher: Oxford University Press
Publication Date: 2015
Language: English
ISBN 10: 0199359016
ISBN 13: 9780199359011
Binding: Soft cover
Edition: 2nd Edition
Condition: New

About this title

Synopsis

Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule and pharmacologic behavior of new agents or new combinations of agents and to describe the adverse effects of treatment. In cancer therapeutics, such studies have particular challenges. Due to the nature of the effects of treatment, most such studies are conducted in patients with advanced malignancy, rather than in healthy volunteers. Further, the endpoints of these trials are usually measures adverse effects rather than molecular target or anti-tumor effects. These factors render the design, conduct, analysis and ethical aspects of phase I cancer trials unique. As the only comprehensive book on this topic, Phase I Cancer Clinical Trials is a useful resource for oncology trainees or specialists interested in understanding cancer drug development. New to this edition are chapters on Phase 0 Trials and Immunotherapeutics, and updated information on the process, pitfalls, and logistics of Phase I Trials

About the Author

EAE: Head, Department of Oncology, Queen's University, Medical Director, Oncology Program, Kingston General Hospital, Cancer Centre of Southeastern Ontario, Kingston, Canada; CT: Professor of Clinical Pharmacology and Oncology, Head, Section of Clinical Cancer Research Groups, Leeds Institute of Cancer Studies and Pathology, St. James's Institute of Oncology Leeds, UK; MB: Founder and Chairman, International Drug Development Institute, Louvain-la-Neuve, Belgium, Associate Professor of Biostatistics, Universiteit Hasselt Diepenbeek, Belgium

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