Photoacoustic Imaging Using Affordable Resources: Bridging the Gap to Clinical Translation (Progress in Optical Science and Photonics, 40)

This book serves as a comprehensive guide to the development and application of cost-effective photoacoustic imaging systems, with a particular emphasis on their potential for clinical translation. As photoacoustic imaging gains traction in both research and clinical settings, the need for affordable, scalable solutions becomes increasingly critical. This book explores the use of budget-friendly light sources, such as LEDs and laser diodes, alongside cost-effective detection schemes, to make this advanced imaging technology accessible to a broader audience. The book also uniquely consolidates practical, end-to-end resources for researchers and system developers—spanning affordable hardware sourcing, open-source reconstruction software, shared datasets, and community platforms—lowering the barrier for students and new laboratories entering the field. Key themes include an in-depth examination of affordable light sources and their integration into imaging systems, as well as a discussion on low-cost detection technologies that balance sensitivity and image quality. The book provides detailed case studies that showcase the successful implementation of these affordable systems in various research and clinical applications, such as cancer detection and vascular imaging. Additionally, it explores the challenges and opportunities of translating these innovations into clinical practice, addressing regulatory considerations and the potential for widespread adoption, particularly in resource-limited settings. Through practical examples, expert insights, and a focus on clinical impact, this book highlights how cost-effective innovations can drive the broader adoption of photoacoustic imaging in healthcare.

Dr. Mithun Kuniyil Ajith Singh is an engineering scientist with extensive experience in preclinical and clinical photoacoustic and ultrasound imaging. He is currently the Research and Business Development Manager at CYBERDYNE Inc., The Netherlands, where he initiates and coordinates international collaborations with leading research institutions worldwide. His primary focus is on bridging the gap between laboratory research and clinical translation of LED-based photoacoustic imaging technology. He currently serves on the editorial board of SPIE’s flagship journal, the Journal of Biomedical Optics, as an Associate Editor. Dr. Mithun obtained his PhD from the University of Twente, The Netherlands, in 2016 under the supervision of Professor Wiendelt Steenbergen, specializing in laser-diode-based photoacoustic system design and image optimization. He has authored and co-authored over 100 scientific publications, including journal papers, book chapters, and conference proceedings, with a primary focus on advancing affordable and accessible photoacoustic imaging technologies. He has also guest-edited special journal issues dedicated to affordable photoacoustic imaging and served as the editor of the first comprehensive book on LED-based photoacoustic imaging, published by Springer Nature in 2020. Through his research, publications, and collaborative initiatives, Dr. Mithun continues to play a leading role in shaping the global landscape of cost-effective, translational photoacoustic imaging.