Physical Methods

Colin F. Chignell

ISBN 10: 1475701985 / ISBN 13: 9781475701982

Published by Springer US, Humana Jan 2013, 2013

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -This volume, the second in the Methods in Pharmacology series, contains some of the physical methods which either have been or could be applied to pharmaco logical problems. A major emphasis has been placed on spectroscopic techniques, particularly those, such as optical rotatory dispersion and circular dichroism, fluorescence spectroscopy, magnetic resonance spectroscopy, ultraviolet absorption spectroscopy, stopped flow and relaxation spectrometry, Mossbauer spectroscopy, light scatter and x-ray crystallography, that can be used to study drug interactions with biological systems at a molecular level. Although phosphorescence spectro scopy and oscillographic polarography can also be used to study drug interactions, their main usefulness is in the detection and estimation of drugs and their meta bolities in body tissues and fluids. Mass spectrometry is a powerful tool for study ing the metabolism of drugs as well as for detecting abnormal endogenous metabolites in the body. Finally, heatburst microcalorimetry is a non spectroscopic technique that can be used to study how drugs and other ligands interact with biological macromolecules. Each chapter contains a brief introduction to the theoretical basis for each technique as well as a description of the instrumentation involved. This is followed by a section describing the application of the technique to pharmacological prob lems. Where these are not available, examples have been drawn from the other life sciences. In a final section, some further applications of each technique to problems in pharmacology are suggested. 512 pp. Englisch.

Seller Inventory # 9781475701982

Bibliographic Details

• Title: Physical Methods
• Publisher: Springer US, Humana Jan 2013
• Publication Date: 2013
• Language: English
• ISBN 10: 1475701985
• ISBN 13: 9781475701982
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 244W x 170H x 28D millimeters 244 millimeters width by 170 millimeters height by 28 millimeters depth
• Weight: 874 grams

About this title

Synopsis

This volume, the second in the Methods in Pharmacology series, contains some of the physical methods which either have been or could be applied to pharmaco­ logical problems. A major emphasis has been placed on spectroscopic techniques, particularly those, such as optical rotatory dispersion and circular dichroism, fluorescence spectroscopy, magnetic resonance spectroscopy, ultraviolet absorption spectroscopy, stopped flow and relaxation spectrometry, Mossbauer spectroscopy, light scatter and x-ray crystallography, that can be used to study drug interactions with biological systems at a molecular level. Although phosphorescence spectro­ scopy and oscillographic polarography can also be used to study drug interactions, their main usefulness is in the detection and estimation of drugs and their meta­ bolities in body tissues and fluids. Mass spectrometry is a powerful tool for study­ ing the metabolism of drugs as well as for detecting abnormal endogenous metabolites in the body. Finally, heatburst microcalorimetry is a non spectroscopic technique that can be used to study how drugs and other ligands interact with biological macromolecules. Each chapter contains a brief introduction to the theoretical basis for each technique as well as a description of the instrumentation involved. This is followed by a section describing the application of the technique to pharmacological prob­ lems. Where these are not available, examples have been drawn from the other life sciences. In a final section, some further applications of each technique to problems in pharmacology are suggested.