Physiologically Based Pharmacokinetic Modeling

Micaela Reddy

ISBN 10: 0471478148 / ISBN 13: 9780471478140

Published by John Wiley and Sons Ltd, 2005

About this Item

This book describes the development of physiologically-based pharmacokinetics (PBPK) modeling for toxic compounds over the past eight decades as well as the current uses of these models. It reviews PBPK model results for various classes of compounds with coverage of historical development, specific modeling challenges and current practices. Num Pages: 420 pages, Illustrations. BIC Classification: PN. Category: (P) Professional & Vocational. Dimension: 239 x 164 x 24. Weight in Grams: 702. . 2005. 1st Edition. Hardcover. . . . . Books ship from the US and Ireland.

Seller Inventory # V9780471478140

Bibliographic Details

• Title: Physiologically Based Pharmacokinetic Modeling
• Publisher: John Wiley and Sons Ltd
• Publication Date: 2005
• Language: English
• ISBN 10: 0471478148
• ISBN 13: 9780471478140
• Binding: Hardcover
• Condition: New

About this title

Synopsis

A definitive, single source of information on PBPK modeling
Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind.
This book presents an overview of the underlying principles of PBPK model development. Then it provides a compendium of PBPK modeling information, including historical development, specific modeling challenges, and current practices for:
* Halogenated Alkanes
* Halogenated Alkenes
* Alkene and Aromatic Compounds
* Reactive Vapors in the Nasal Cavity
* Alkanes, Oxyhydrocarbons, and Related Compounds
* Pesticides and Persistent Organic Pollutants
* Dioxin and Related Compounds
* Metals and Inorganic Compounds
* Drugs
* Antineoplastic Agents
* Perinatal Transfer
* Mixtures
* Dermal Exposure Models
In addition to pinpointing specific information, readers can explore diverse modeling techniques and applications. An authoritative reference for toxicologists, ecotoxicologists, risk assessors, regulators, pharmacologists, pharmacists, and graduate students in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles information from leaders in the field and discusses future directions for PBPK modeling.

About the Author

The EDITORS have worked together on PBPK research and in teaching PBPK modeling workshops and courses through the Quantitative and Computation Toxicology research group at the Center for Environ-mental Toxicology and Technology (CETT) in the Department of Environmental and Radiological Health Sciences at Colorado State University (CSU).

MICAELA B. REDDY, PhD, is a research professor at CETT where she has developed PBPK models for risk assessment and toxicology applications.

RAYMOND S. H. YANG, PhD, Professor of Toxicology and former director, CETT, championed applications of PBPK modeling in research on the toxicology of chemical mixtures.

HARVEY J. CLEWELL III, MS, Director, Center for Human Health Assessment, CIIT Centers for Health Research, Research Triangle Park, North Carolina, played a major role in the first uses of PBPK modeling in cancer and non-cancer risk assessments by several federal agencies, including EPA, ATSDR, OSHA, and FDA.

MELVIN E. ANDERSEN, PhD, a pioneer in use of PBPK modeling in toxicology and risk assessment, is Director, Computational Biology Division, CIIT Centers for Health Research, Research Triangle Park, North Carolina.