Plant Gums in the Formulation of Paracetamol Tablets

In view of importance of binders in pharmaceuticals for the manufacture of tablets and capsules, gum was isolated from the seeds of Cassia roxburghii Linn, and the bark of Moringa oleifera. The binding properties of both gums were evaluated in relation to conventional binder like guar gum, gelatin, Sod.CMC .Increase in concentration of filtered and defatted C. roxburghii gum, M.oleifera gum from 2% to 6%; decrease the percentage of fine, increase the hardness, increase the disintegration time, decrease the percentage of friability and decrease % cumulative release. Hence Paracetamol tablets were formulated using combination of (1% C.rox+1%M.oleifera) binding concentration and evaluated.. Results indicates that Paracetamol tablets prepared with 2 % ( 1% C. roxburghii + 1% M. oleifera) of mucilage were found to be ideal for the preparation of uncoated tablet formulation when high mechanical strength is more essential and hence these gums shows better tabletting characteristics and have high potentials for the substitution for more expensive binders.

M.R. Shivalingam M.Pharm (Ph.D),from Tamil Nadu Dr.M.G.R Medical University, Chennai specialised in Pharmaceutics, worked for Novartis as Product specialist for 5 Years.Currently working as Asst.Prof (5Yrs) in Victoria College of Pharmacy, Guntur, Andhra Pradesh. Focusing on TDDS and serving as Reviewer, Editorial Board member in Int.Pharmacy journals.