This Reprint describes many facets of the molecular 'tug of war' of plant-pathogen interactions. They span the manipulation of salicylic acid metabolism and peptide-triggered immune regulation, the coordinated control of bacterial virulence systems, fungal reliance on protein-targeting and cell-wall-degrading enzymes, viral hijacking of host cytoskeletal and nuclear components, and microbiome-mediated enhancement of plant defense and stress tolerance. Together, the nine papers provide a timely and integrated view of plant-pathogen interactions, advancing our understanding of susceptibility genes, pathogen regulatory networks, effector biology, cell-wall degradation, viral movement, beneficial microbe-mediated defense activation, and rhizosphere-driven resilience.

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