Polyphenols in Health: Bioavailability, Mechanisms, and Therapeutic Innovations

This book offers a comprehensive overview of the latest research on polyphenols, highlighting their crucial role in preventing and managing chronic diseases. Divided into five parts, the book begins with the fundamental aspects of polyphenols, including their classification, dietary sources, bioavailability, and interactions with the gut microbiota. The subsequent sections explore the mechanisms by which polyphenols exert their beneficial effects, particularly in cardiovascular health, cancer prevention, diabetes management, neuroprotection, weight management, and inflammatory conditions. The latter part of the book discusses innovative approaches to enhance polyphenol delivery and utilization, such as nanotechnology and functional foods. It also addresses critical considerations, including safety, toxicity, and drug-nutrient interactions.

Given its breadth, this book is a valuable resource for researchers, scholars, and practitioners in nutrition, medicine, and food science. It also appeals to professionals working for regulatory bodies and the industry, in the areas of chemical and biochemical engineering, quality certification systems, and food processing environments.

Rajeev K. Singla is an Assistant Researcher at the Institutes for Systems Genetics, West China Hospital, Sichuan University. He holds a PhD in Natural Product Chemistry, has published 150+ SCI articles, and serves as Founder and Chief Editor of an international pharmaceutical journal. According to Scopus, he has published papers with more than 800 co-authors from 40 countries so far. He is also associated with European Society of Clinical Microbiology and Infectious Diseases (ESCMID) as Local Champions (China) and ESCMID Research Grant Evaluator.

Vivek P. Chavda is an Assistant Professor and BPharm/MPharm Gold Medalist from Gujarat Technological University. With nearly eight years of biologics industry experience, he has authored 170+ publications, multiple book chapters, and contributes to translational biopharmaceutical research and innovation.

Tapan Behl is a Professor and Head of Pharmaceutical Sciences at Amity University, Punjab, with over 15 years of academic and research experience. He holds a PhD in Medical Pharmacology, has published extensively, holds patents, and focuses on neuropharmacology, molecular pharmacology, drug repurposing, and translational therapeutics.

Salvatore Parisi is an Honorary Professor in Food Safety, with a PhD from University of Messina. He is known for Parisi’s First Law of Food Degradation and international teaching roles, with 330+ publications. Parisi currently serves in the AOAC Official Methods Board, USA.

Bairong Shen is Professor and Executive Director‑General at the Institutes for Systems Genetics, West China Hospital, Sichuan University. Trained as a chemist, he leads research in biomedical informatics, systems biology, and AI-driven disease modeling, with over 300 peer-reviewed publications.