Polyploidization and Cancer

Randy Y. C. Poon

ISBN 10: 1493951432 / ISBN 13: 9781493951437

Published by Springer New York, Springer US, 2016

About this Item

Druck auf Anfrage Neuware - Printed after ordering - Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overviewsubjects relating to polyploidization and cancer.

Seller Inventory # 9781493951437

Bibliographic Details

• Title: Polyploidization and Cancer
• Publisher: Springer New York, Springer US
• Publication Date: 2016
• Language: English
• ISBN 10: 1493951432
• ISBN 13: 9781493951437
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 254W x 178H x 10D millimeters 254 millimeters width by 178 millimeters height by 10 millimeters depth
• Weight: 329 grams

About this title

Synopsis

Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.

About the Author

Randy Y.C. Poon is a professor of Biochemistry at the Hong Kong University of Science and Technology. He was educated at Tonbridge School and received his Master of Arts degree from St. Catharine’s College at the University of Cambridge. He then studied for a Doctor of Philosophy degree at the University of Cambridge and Cancer Research UK with Tim Hunt, FR S. Dr. Poon conducted postdoctoral training at the Salk Institute with Tony Hunter, FR S. Dr. Poon is a member of Editorial Board of numerous international journals, including the Biochemical Journal and Cancer Biology and Therapy. His research interests focus on understanding the molecular basis of cell cycle control in normal and cancer cells.