Postlabelling Methods for Detection of DNA Adducts. (= IARC Scientific Publications - No. 124).

Phillips, D.H., Castegnaro, M., Bartsch, H. (Editors).:

ISBN 10: 9283221249 / ISBN 13: 9789283221241

Published by International Agency for Research on Cancer, Lyon, 1993

About this Item

392 S. mit zahlreichen Abbildungen, 9283221249 Sprache: Englisch Gewicht in Gramm: 840 Groß 8°, Original-Karton, gutes Exemplar, (soft cover, good copy),

Seller Inventory # 41139

Bibliographic Details

• Title: Postlabelling Methods for Detection of DNA Adducts. (= IARC Scientific Publications - No. 124).
• Publisher: International Agency for Research on Cancer, Lyon
• Publication Date: 1993
• Language: English
• ISBN 10: 9283221249
• ISBN 13: 9789283221241
• Binding: Soft cover
• Weight: 840 grams
• Seller catalogs:
  • Kernphysik, Kernchemie, Nuklearmedizin

About this title

Synopsis

In experimental animal studies, the quantitation of DNA adducts has usually required the use of highly radioactive chemical carcinogens. However, a major breakthrough in detection methods occurred in the early 1980s with the development of the 32P-postlabelling technique. Today, at least 60 laboratories have employed and customized these methods. The conference upon which this volume is based was the first time that the majority of these investigators met to discuss their research. A unique aspect of this meeting was an international effort by 15 different laboratories to quantify carcinogen-DNA adduct level in chemically modified DNA standards and in human tissue samples. The application of 32P-postlabelling together with various biomonitoring techniques as described in this volume marks the beginning of a new approach to human risk assessment based on carcinogen-DNA adducts as molecular biomarkers that are expected to be predictive of clinical disease.

About the Author

D. H. Phillips is at Haddow Laboratories, Belmont, Sutton, Surrey. M. Castegnaro is at IARC, Lyon.