Postmenopausal Hormone Therapy and the Risk for Uterine Cancers

Jaakkola, Susanna; Pukkala, Eero; Ylikorkala, Olavi

ISBN 10: 365923396X / ISBN 13: 9783659233968

Published by VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2012

About this Item

Print on Demand pp. 112 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam.

Seller Inventory # 131774902

Bibliographic Details

• Title: Postmenopausal Hormone Therapy and the Risk for Uterine Cancers
• Publisher: VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG
• Publication Date: 2012
• Language: English
• ISBN 10: 365923396X
• ISBN 13: 9783659233968
• Binding: Soft cover
• Condition: New

About this title

Synopsis

Large differences exist between countries in the context and use of postmenopausal hormone therapies. Differences also exist in genes, diet and lifestyle, which all affect the risk for cancers. I studied the effects of different estrogen-progestagen therapies (EPT) for the risk of endometrial and cervical cancer as well as uterine sarcoma in nationwide studies on postmenopausal Finnish women. The use of postmenopausal EPT is one determinant for the occurrence of uterine cancers. Continuous combined regimens decrease and sequential regimens increase the risk for endometrial cancer; these data support earlier findings. The following new observations were made; oral and transdermal routes of administration or various types of progestagens do not modify these effects. A consistent decrease in the incidence of squamous cervical malignancies was seen in EPT users. In contrast, the incidence of cervical adenocarcinoma was increased. The risk for uterine sarcomas is increased if EPT has been used for longer times. These data are of importance for the potential users of EPT and for physicians prescribing such regimens.

About the Author

MD, PhD, is a gynecologist from Helsinki University Hospital, Finland.