Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase II trial, including issues such as how the treatment works, choice of outcome measure and randomization, and considering both academic and industry perspectives. A comprehensive and systematic library of available phase II trial designs is included, saving time otherwise spent considering multiple manuscripts, and real-life practical examples of using this approach to design phase II trials in cancer are given.

A Practical Guide to Designing Phase II Trials in Oncology:

Offers a structured and practical approach to phase II trial design
Considers trial design from both an academic and industry perspective
Includes a structured library of available phase II trial designs
Is relevant to both clinical and statistical researchers at all levels
Includes real life examples of applying this approach

For those new to trial design, A Practical Guide to Designing Phase II Trials in Oncology will be a unique and practical learning tool, providing an introduction to the concepts behind informed decision making in phase II trials. For more experienced practitioners, the book will offer an overview of new, less familiar approaches to phase II trial design, providing alternative options to those which they may have previously used.

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Sarah Rose Brown, Walter M. Gregory, Christopher J. Twelves, and Julia M. Brown, Clinical Trials Research Unit, University of Leeds, UK

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Practical Guide to Designing Phase II Trials in Oncology

Brown, Sarah R.; Gregory, Walter M.; Twelves, Chris; Brown, Julia

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