This is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. This new edition is fully updated with much more molecular, screening and management information. It covers risk analysis and genetic counseling for individuals with a family history of cancer, and also discusses predictive testing and the organization of the cancer genetics service. It aims to provide such details in a practical format for geneticists and clinicians in all disciplines. This book differs from others in the field in that it is a practical handbook for easy reference for a wide clinical audience. There is a large reference list for further details, as well as information about the genes causing mendelian cancer predisposing condition and their mechanism of action.

About the Authors

Shirley Hodgson is Professor of Cancer Genetics at St George's Hospital Medical School.

Eamonn Maher is Professor of Medical Genetics and Head of Section of Medical and Molecular Genetics at the University of Birmingham School of Medicine's Institute of Biomedical Research. He is also Editor-in-Chief of the Journal of Medical Genetics.

Charis Eng is Professor and Director of the Genomic Medicine Institute, Cleveland Clinic Foundation, and Professor and Vice Chairman of the Department of Genetics, Case Western Reserve University School of Medicine.

William Foulkes is the Director of the Program in Cancer Genetics, Departments of Oncology and Human Genetics, and Associate Professor of the Department of Medicine, McGill University, Montreal.

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