Preclinical Drug Development, Second Edition discusses the broad and complicated realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology to industry trends and regulatory expectations to requirements that support clinical trials.

Highlights of the Second Edition include:

Pharmacokinetics
Modeling and simulation
Formulation and routes of administration
Toxicity evaluations
The assessment of drug absorption and metabolism
Interspecies scaling
Lead molecule selection and optimization via profiling
Screening using in silico and in vitro toxicity evaluations

The book also includes case studies on preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development, a review of ICH preclinical guidelines, and experimental methods used to study membrane drug transport and metabolism. This guide is a fundamental resource for medicinal chemists, biologists, and other specialists in the drug development sciences.

About the Author

Mark Rogge, David R. Taft

"About this title" may belong to another edition of this title.

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