Prediction of Aqueous Solubility from SCRATCH | A new approach for solubility estimation

Parijat Jain

ISBN 10: 3639162692 / ISBN 13: 9783639162691

Published by VDM Verlag Dr. Müller, 2009

About this Item

Prediction of Aqueous Solubility from SCRATCH | A new approach for solubility estimation | Parijat Jain | Taschenbuch | Englisch | VDM Verlag Dr. Müller | EAN 9783639162691 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 101543189

Bibliographic Details

• Title: Prediction of Aqueous Solubility from SCRATCH | A new approach for solubility estimation
• Publisher: VDM Verlag Dr. Müller
• Publication Date: 2009
• Language: English
• ISBN 10: 3639162692
• ISBN 13: 9783639162691
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

Written for researchers in the chemical and pharmaceutical field, who deal with solubility, this book proposes a unique way of predicting aqueous solubility directly from the structure of a compound. The algorithm termed ¿SCRATCH model¿ utilizes predicted melting points and aqueous activity coefficients for the solubility estimation. Both the melting point and aqueous activity coefficient predictions are individually trained on over 1600 organic compounds, making the model very rigorous and robust. The model is cross- validated on about 900 organic compounds for the aqueous solubility prediction. In addition, the three appendices provide a lot of useful information for the reader.

About the Author

Dr. P. Jain is a Senior Scientist at Novartis Pharmaceuticals Corporation, East Hanover, NJ. He received his Ph.D. from University of Arizona. Dr. S. H. Yalkowsky is Professor of Pharmaceutical Sciences at the University of Arizona, Tucson, AZ.