Principles of Genome Analysis: A Guide to Mapping and Sequencing DNA from Different Organisms

Genome analysis and genomics are at the forefront of current research in the life sciences. Since the first edition of Principles of Genome Analysis was published, the sequencing of genomes has continued apace, with the major landmark of the human genome sequence being achieved in 2001. Now the emphasis of biological research is on genomics: the understanding of gene function and the interaction of gene products at the whole genome level.

As before, this book provides a step-by-step outline of the techniques involved in genome mapping and sequencing. Additionally, the text has been greatly expanded to cover sub-disciplines of genomics, revisions of sections on genome sequencing and bioinformatics, and new chapters on comparative genomics, functional genomics and proteomics. The book concludes with an exciting new chapter describing a variety of ways to utilize genome analysis and sequencing in biology, medicine and agriculture.

Aimed at advanced undergraduates, this text will follow the same format as the highly successful Principles of Gene Manipulation by Primrose, Twyman and Old, now in its sixth edition.

Genome analysis remains high on the agenda for research in the life sciences. Since the first edition of Principles of Genome Analysis appeared, the sequencing of model genomes has continued to gather momentum, culminating in the publication of the first complete genomes of several species of bacteria and eukaryotic microbes. Living up to its title the book provides a step-by-step outline of the techniques of gene mapping. It has been fully revised and expanded for the second edition, and features a new chapter on sequence data analysis. Produced in two colours throughout and profusely illustrated, Principles of Genome Analysis is ideal as a course text for students of molecular genetics, genome analysis and molecular biotechnology