Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA).

This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.

• Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge
• Defines technical terms for novices
• Includes a complete list of resources, including relevant online databases and software, as well as useful websites

Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.

Mark Sanderson is a Visiting Professor of Biophysics in the Dept of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London. Recent structural studies in his laboratory have centred on type-II topoisomerase–DNA–drug complexes in collaboration with Prof. Mark Fisher’s group at St. George’s University of London using cryo-EM and X-ray crystallography, and the study of novel nucleic acid–protein complexes.