Process Optimization of Diclofenac Sodium Sustained Release Tablet

Balkrushna K. Patel

ISBN 10: 3847302833 / ISBN 13: 9783847302834

Published by LAP LAMBERT Academic Publishing Nov 2011, 2011

About this Item

Neuware -In this work an attempt has been done to optimize the process of tabletting and enteric coating for Diclofenac sodium enteric coated tablet. Various optimized parameters are Blending, Granulation, Compression, and Coating. All materials required for preparing Diclofenac 50mg enteric coated tablet were accurately dispensed under specified condition. Optimization was done based on determining the relationship between independent variable and dependent variable. Independent variable like blending time before granulation was optimized based on content uniformity. Spray rate of binder for granulation was optimized for uniform and satisfied physical characterization. Spray rate of enteric coating suspension was optimized for efficient coating and process.Books on Demand GmbH, Überseering 33, 22297 Hamburg 92 pp. Englisch.

Seller Inventory # 9783847302834

Bibliographic Details

• Title: Process Optimization of Diclofenac Sodium Sustained Release Tablet
• Publisher: LAP LAMBERT Academic Publishing Nov 2011
• Publication Date: 2011
• Language: English
• ISBN 10: 3847302833
• ISBN 13: 9783847302834
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 6D millimeters 220 millimeters width by 150 millimeters height by 6 millimeters depth
• Weight: 155 grams

About this title

Synopsis

In this work an attempt has been done to optimize the process of tabletting and enteric coating for Diclofenac sodium enteric coated tablet. Various optimized parameters are Blending, Granulation, Compression, and Coating. All materials required for preparing Diclofenac 50mg enteric coated tablet were accurately dispensed under specified condition. Optimization was done based on determining the relationship between independent variable and dependent variable. Independent variable like blending time before granulation was optimized based on content uniformity. Spray rate of binder for granulation was optimized for uniform and satisfied physical characterization. Spray rate of enteric coating suspension was optimized for efficient coating and process.

About the Author

Balkrushna K. Patel, M. Pharm, (Ph.D.) is an Asst. Professor at K J College of Pharmacy. He has two international publications to his credit. Bhuvan P. Raval, M. Pharm, PGDPRA, MBA, (Ph.D), FSAB is an Asst. Professor at K J College of Pharmacy. Bhavik A. Patel, M. Pharm, (Ph.D.) is an Asst. Professor at K J College of Pharmacy.