Process Optimization of Diclofenac Sodium Sustained Release Tablet: Dosage Form Development

Patel, Balkrushna K.; Raval, Bhuvan P.; Patel, Bhavik A.

ISBN 10: 3847302833 / ISBN 13: 9783847302834

Published by LAP LAMBERT Academic Publishing, 2011

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Bibliographic Details

• Title: Process Optimization of Diclofenac Sodium Sustained Release Tablet: Dosage Form Development
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2011
• Language: English
• ISBN 10: 3847302833
• ISBN 13: 9783847302834
• Binding: Soft cover
• Condition: New

About this title

Synopsis

In this work an attempt has been done to optimize the process of tabletting and enteric coating for Diclofenac sodium enteric coated tablet. Various optimized parameters are Blending, Granulation, Compression, and Coating. All materials required for preparing Diclofenac 50mg enteric coated tablet were accurately dispensed under specified condition. Optimization was done based on determining the relationship between independent variable and dependent variable. Independent variable like blending time before granulation was optimized based on content uniformity. Spray rate of binder for granulation was optimized for uniform and satisfied physical characterization. Spray rate of enteric coating suspension was optimized for efficient coating and process.

About the Author

Balkrushna K. Patel, M. Pharm, (Ph.D.) is an Asst. Professor at K J College of Pharmacy. He has two international publications to his credit. Bhuvan P. Raval, M. Pharm, PGDPRA, MBA, (Ph.D), FSAB is an Asst. Professor at K J College of Pharmacy. Bhavik A. Patel, M. Pharm, (Ph.D.) is an Asst. Professor at K J College of Pharmacy.