Processing of Vegf-C and -D by the Proprotein Convertases : Importance in Angiogenesis, Lymphangiogenesis, and Tumorigenesis

Language: English

Published by Biota Publishing, 2013

1615046100 / 9781615046102

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nach der Bestellung gedruckt Neuware - Printed after ordering - The vascular endothelial growth factor (VEGF) family members that include VEGF-A, -B, -C, -Dand placental growth factor (PlGF), display distinct binding affinities for their receptors VEGFR-12, and/or -3. In addition to their requirements in the initiation, development, and maintenance ofblood and lymphatic vasculature, VEGFs and VEGFRs are upregulated during neoplasia and areinvolved in the remodeling of tumoral blood and lymphatic vasculature. By activating VEGFR-1and VEGFR-2, both expressed on blood endothelial cells, VEGF-A promotes the formation ofnew tumoral blood vessels and thereby accelerates tumor growth. In contrast, upregulation ofVEGF-C, a ligand for lymphatic endothelial VEGFR-3 as well as for VEGFR-2, induces theformation of tumor-associated lymphatic vessels and thus promotes the passive metastatic disseminationof tumor cells to regional lymph nodes. Of the VEGF family members, only VEGF-C andD were found to be proteolytically processed by Furin-like enzymes. This processing controlsthe selective activation of VEGFR-2 and -3 signaling during tumor angiogenesis and lymphangiogenesis.Here, we provide an overview of angiogenesis processes and discuss the importance ofVEGF-C and VEGF-D precursors processing by the proprotein convertases during the activationof VEGFR-2 and VEGFR-3 receptors and the mediation of their functions during angiogenesislymphangiogenesis, and tumorigenesis.

Seller Inventory # 9781615046102

Title
Processing of Vegf-C and -D by the Proprotein Convertases : Importance in Angiogenesis, Lymphangiogenesis, and Tumorigenesis
Author
Geraldine Siegfried
Publisher
Biota Publishing
Publication year
2013
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
1615046100
ISBN 13
9781615046102
Item weight
143 grams
Dimensions
235x191x4 mm

AHA-BUCH GmbH

Einbeck, Germany

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