Properties of Copper (Metal Ions in Biological Systems, Volume 12)

Sigel, Helmut, Sigel, Astrid

ISBN 10: 0824714296 / ISBN 13: 9780824714291

Published by Marcel Dekker Inc, 1981

About this Item

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Seller Inventory # ERICA79008247142966

Bibliographic Details

• Title: Properties of Copper (Metal Ions in Biological Systems, Volume 12)
• Publisher: Marcel Dekker Inc
• Publication Date: 1981
• Language: English
• ISBN 10: 0824714296
• ISBN 13: 9780824714291
• Binding: Hardcover
• Condition: Very Good
• Dust Jacket Condition: Dust Jacket Included
• Book Type: book

About this title

Synopsis

Volume 32 covers metal ion bonding to phosphate, sugar and nucleobase residues; the ambidentate as well as the stacking properties of nucleotides; kinetic aspects as well as properties of nucleobase and nucleotide analogs; and the oligonucleotides and nucleic acids. It examines electron transfer reactions over a large number of base repairs in DNA, the role of metal ions in ribozymes, ternary metal-nucleic acid base-protein complexes, metal responsive gene regulation, and the structure-activity relationships of anticancer drugs and their action on DNA, including cisplatin and the role of proteins.

From the Back Cover

Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic and coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry.

Volume 1, offers in 15 stimulating chapters an authoritative view of the fascinating research on Neurodegenerative Diseases and Metal Ions. Written by 41 internationally recognized experts, ithighlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalo­pathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized. With more than 2000 references this book is a vital resource for scientists and advanced students.