A Prospective Immunological and Genetic Study of Infertile Men: How Can Antisperm Antibodies and Chromatin Disintegrity Affect Male Infertility

Alfahham, Ali; Al-Sultani, Yahya; Mohammad-Ali, Abdulzahra

ISBN 10: 3330054190 / ISBN 13: 9783330054196

Published by LAP LAMBERT Academic Publishing, 2017

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Bibliographic Details

• Title: A Prospective Immunological and Genetic Study of Infertile Men: How Can Antisperm Antibodies and Chromatin Disintegrity Affect Male Infertility
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2017
• Language: English
• ISBN 10: 3330054190
• ISBN 13: 9783330054196
• Binding: Soft cover
• Condition: New

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Synopsis

It is a scientific fact today that routine seminal fluid analysis is a key predictor of male reproductive potentiality; so that there is an increasing need for finding out other functional tests in the assessment of male infertility. The main goal of the current study is to consolidate the scientific and practical efforts concerned with male infertility assessment especially from immunological and genetic aspects. The current study concluded that the defects in sperm chromatin status (chromatin decondensation and DNA damage), and the immunological disorders caused by serum and seminal plasma ASA may - at least partially– contribute to the etiology of infertility of the patients under study, even in those with normal seminal parameters. However, it seems that ASA affect fertility in a pathway that is different from that affected by sperm chromatin defect. It was recommended that both sperm chromatin staining techniques and ASA tests could be routinely used as complementary tests to diagnose infertility.

About the Author

Ali Abdulzahra M. Al-fahham: Qualifications: Ph.D. /Biology/physiology: from the Faculty of Science, University of Kufa, in 2014. The title of my thesis was: "A prospective Immunological and Genetic Study of Infertile Men". Occupations: 1.Head of the Department of the basic medical sciences.2.Secretary of Faculty Council.