Prostaglandins and Control of Vascular Smooth Muscle Cell Proliferation

Language: English

Published by Birkhäuser, Birkhäuser Mär 2012, 2012

3034873549 / 9783034873543

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This item is printed on demand - Print on Demand Titel. Neuware -Uncontrolled proliferation of vascular smooth muscle cells (SMC) in response to vessel injury is a problem with a considerable therapeutic impact. Specifically, restenosis after percutaneous transluminal coronary angioplasty (PTCA) is a clinical problem without any effective drug therapy so far. Thus, there is need for an improved drug therapy but also for an improved understanding of the pathophysiology of growth control in SMC. Cyclooxygenase products, such as prostaglandins and thromboxane, are intimately involved in growth responses. Vasodilatory prostaglandins, such as PGI , PGE or their analogues, have 2 1 been shown to inhibit SMC proliferation. There is also evidence for a markedly increased endogenous prostaglandin production during neointirna formation under the influence of growth factors which includes induction of COX-2. These data suggest that prostaglandins might be considered both targets and tools of growth control. However, there are still many open questions, including the possible interaction of prostaglandins with other growth modulating factors, in particular NO, the intracellular signal transduction pathways and the role of oxidative stress.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 140 pp. Englisch.…

Seller Inventory # 9783034873543

Title
Prostaglandins and Control of Vascular Smooth Muscle Cell Proliferation
Author
K. Schrör
Publisher
Birkhäuser, Birkhäuser Mär 2012
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3034873549
ISBN 13
9783034873543
Item weight
224 grams
Dimensions
235x155x8 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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