Prostate Cancer: Cellular and Genetic Mechanisms of Disease Development and Progression

The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis.

Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.

Scott Dehm is Professor in the Departments of Laboratory Medicine and Pathology and Urology at University of Minnesota.  He holds the Apogee Enterprises Chair of Cancer Research at the Masonic Cancer Center, University of Minnesota.  He obtained his Ph.D. degree in Biochemistry from the University of Saskatchewan.

Donald Tindall is Professor Emeritus in the Departments of Biochemistry and Molecular Biology and Urology at Mayo Clinic.  He obtained his Ph.D. degree from the University of North Carolina at Chapel Hill.