Proteases and Their Inhibitors in Cancer Metastasis

R J Muschel

ISBN 10: 1402009232 / ISBN 13: 9781402009235

Published by Springer Jul 2003, 2003

About this Item

Neuware - In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account. This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.

Seller Inventory # 9781402009235

Bibliographic Details

• Title: Proteases and Their Inhibitors in Cancer Metastasis
• Publisher: Springer Jul 2003
• Publication Date: 2003
• Language: English
• ISBN 10: 1402009232
• ISBN 13: 9781402009235
• Binding: Buch
• Condition: Neu
• Dimensions: 252W x 156H x 17D millimeters 252 millimeters width by 156 millimeters height by 17 millimeters depth
• Weight: 599 grams

About this title

Synopsis

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account.
This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.