Protein Complexes that Modify Chromatin

Language: English

Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2003, 2003

3540442081 / 9783540442080

Series: Book 165 of 322 - Current Topics in Microbiology and Immunology

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This item is printed on demand - Print on Demand Titel. Neuware -An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans acting factors. Our view of eukaryotic chromosomes has evolved dra matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Chromatin dynamics is a consequence of protein complexes that modify histones, remove histone modifications, mobi lize nucleosomes or stabilize nucleosomes. Awide variety of such com plexes have now been described. Some are abundant and may play glo bal roles in chromosome fluidity and function. Others are more rare and specialized for specific functions at discreet loci. Moreover, several complexes share biochemical activities and genetic studies suggest overlapping functions in vivo. Many components of these complexes were first revealed in genetic screens, while others were discovered by novel cell biological or biochemical approaches.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 316 pp. Englisch.

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Title
Protein Complexes that Modify Chromatin
Author
Jerry L. Workman
Publisher
Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2003
Publication year
2003
Condition
Neu
Binding
Buch
Language
English
ISBN 10
3540442081
ISBN 13
9783540442080
Item weight
641 grams
Dimensions
241x160x22 mm
Series
Book 165 of 322: Current Topics in Microbiology and Immunology

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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