Protein Phosphorylation

Claude Prigent

ISBN 10: 9535136259 / ISBN 13: 9789535136255

Published by Intechopen Nov 2017, 2017

About this Item

Neuware -Protein phosphorylation reactions are carried out in a cell by protein kinases, which predominantly use ATP as a phosphate donor that is transferred and covalently bound to an amino acid on a substrate protein. Protein phosphorylation was discovered in 1954 by Edmond Fischer who shared the Nobel Prize in Medicine or Physiology in 1992 with Edwin Krebs. There are so many kinases that one was called 'Just Another Kinase' for JAK kinase. Their counterpart is protein phosphatases that remove phosphates from phosphorylated proteins. Kinases and phosphatases act as switches in the cell that activates or inactivates protein functions. These reactions are reversible; the cell can quickly react to a situation but can then go back to its initial state.Books on Demand GmbH, Überseering 33, 22297 Hamburg 204 pp. Englisch.

Seller Inventory # 9789535136255

Bibliographic Details

• Title: Protein Phosphorylation
• Publisher: Intechopen Nov 2017
• Publication Date: 2017
• Language: English
• ISBN 10: 9535136259
• ISBN 13: 9789535136255
• Binding: Buch
• Condition: Neu
• Dimensions: 266W x 185H x 19D millimeters 266 millimeters width by 185 millimeters height by 19 millimeters depth
• Weight: 659 grams

About this title

Synopsis

Protein phosphorylation reactions are carried out in a cell by protein kinases, which predominantly use ATP as a phosphate donor that is transferred and covalently bound to an amino acid on a substrate protein. Protein phosphorylation was discovered in 1954 by Edmond Fischer who shared the Nobel Prize in Medicine or Physiology in 1992 with Edwin Krebs. There are so many kinases that one was called "Just Another Kinase" for JAK kinase. Their counterpart is protein phosphatases that remove phosphates from phosphorylated proteins. Kinases and phosphatases act as switches in the cell that activates or inactivates protein functions. These reactions are reversible; the cell can quickly react to a situation but can then go back to its initial state.