Protein-Protein Interactions : Pathophysiological and Therapeutic Aspects

The second volume of the book-Protein-Protein Interactions (PPIs) provides an overview of various protein-protein interactions (PPIs) that are involved in various human diseases including cancer, neurodegenerative diseases, immune diseases, and inflammation. It summarizes the structure and ligand-based drug designing approaches for the discovery of small molecules that can inhibit PPIs in these diseases.

The book discusses different computational and experimental tools that are used to determine the anomalous interactions underlying the diseases.

Lastly, it also reviews the classical interactions between pathogens and hosts that are responsible for the pathophysiology of infectious diseases.

Dr. Krishna Mohan Poluri is currently working as an Associate Professor at Department of Biosciences and Bioengineering, and Centre for Nanotechnology at Indian Institute of Technology Roorkee (IIT-Roorkee). Dr. Poluri completed his PhD from Tata Institute of Fundamental Research TIFR-Mumbai, and Post-doc from Rutgers University & University of Texas Medical Branch (UTMB-Texas). His areas of expertise are Protein Biochemistry & Biophysics, Bio-molecular Interactions, Structural Biology, Glycoimmunology, Bionanotechnology and Algal Biotechnology etc. He has published ~ 160 publications including Research articles, editorials, books and book chapters in various reputed international Journals. Dr. Poluri is also a guest editor/editorial board member and adhoc reviewer for several international research journals. He won several awards and fellowships for his research work. Most prominent are: Ashok Soota institute research fellow (2021), Young scientist awards from Indian ScienceCongress association (ISCA) -2009, National Academy of Sciences India (NASI)-2014, and Innovative Young Biotechnologist Award (IYBA)-2013 by DBT.

Dr. Khushboo Gulati has completed her PhD in the area of “Protein Biophysics” at Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT), Roorkee. Dr. Gulati completed her Bachelors in Bioinformatics and Masters in Biotechnology from Punjab University, India. Her Research interests are in the area of Protein-Protein Interactions, Protein Engineering, Molecular Biophysics, and Structural Biology. Dr. Gulati has authored around 20 peer reviewed publications in SCI indexed international journals, 4 book chapters and 2 books. Dr. Gulati is a recipient of ICMRBS young scientist award.

Mr. Deepak Kumar Tripathi is currently working as a Research Scholar at Mechanistic Biological Chemistry Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT), Roorkee.He has completed his Bachelor’s in Biotechnology from Uttar Pradesh Technical University (UPTU), Lucknow, in 2014. Mr. Tripathi completed his Master’s degree in Industrial Biotechnology from National Institute of Technology Karnataka (NITK), Surathkal, in 2017. His research interests are in the area of Protein Engineering, Protein-Ligand Interactions, Molecular Biophysics, and Structural Biology.

Ms. Nupur Nagar is currently working as a Research Scholar at Mechanistic Biological Chemistry Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT), Roorkee. Ms. Nagar completed her Master’s degree in Plant Biotechnology from TERI University, New Delhi in 2017. Her research interest is in the protein engineering, structural biology, bioinformatics, and data analytics.