The three-dimensional structure of proteins is a key factor in their biological activity. There is an increasing need to be able to predict the structure of a protein once its amino-acid sequence is known; this book presents practical methods of achieving that ambitious aim, using the latest computer modelling algorithms. Editor(s): Sternberg, Michael J. E. Series: Practical Approach Series. Num Pages: 318 pages, colour plates, halftones, line figures, tables. BIC Classification: PSBC; TCB; UGK. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 18. Weight in Grams: 451. . 1997. paperback. . . . .

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Bibliographic Details

Title: Protein Structure Prediction: A Practical Approach: 170 (Practical Approach Series)
Publisher: Oxford University Press, USA
Publication Date: 1997
Language: English
ISBN 10: 0199634963
ISBN 13: 9780199634965
Binding: Soft cover
Condition: New

About this title

Synopsis

The prediction of the three-dimensional structure of a protein from its amino acid sequence is a problem faced by an increasing number of biological scientists. This book provides a practical guide to making these predictions by reviewing strategies of different computer modeling algorithms and highlighting the degree of confidence attributed to them. Also in the volume are descriptions of the following: the principles of protein folding; sequence homology and motif searches; prediction of secondary structure; homology modeling; modeling of antibody combining sites; tertiary fold recognition; modeling of transmembrane proteins; ab initio prediction; protein-ligand docking simulations; and the use of molecular mechanics and dynamics. both non-specialists who require guidance to identify and evaluate appropriate strategies and experts who require a contemporary view of the field, will find this volume a worthy addition to their research libraries.

About the Author

M. Sternberg is at Imperial Cancer Research Fund, London.

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