Protocols for Adult Stem Cells

Irina M. Conboy

ISBN 10: 1607610620 / ISBN 13: 9781607610625

Published by Humana Press Apr 2010, 2010

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -Although embryonic stem cells currently enjoy the public limelight and show great pr- ise for cell based medical therapies, it is the adult stem cells which are responsible for the body's natural ability to fght disease, heal and recover, or fail and succumb to various maladies. The study of mammalian adult stem cells has surged recently, most likely from a maturation of stem cell studies in the classical developmental model organisms and in hematopoeisis. All the tissues of the body examined so far are generated and regenerated from stem cells, it has been an important frst step to adapt or devise new methods to identify and obtain these cells in quantity and purity for further study. Culture techniques have been optimized for managing the growth and differentiation of stem cells in vitro; as some stem cells are pluripotent, often the method is to guide the fate of such cells among the possible differentiation fates. Much of this work, and that in the classical model org- isms, has helped defne the aspects of the stem cell environment or niche that are crucial for both growth and differentiation, and these studies have moved in vivo at increasingly higher resolution. Importantly, the in vivo niche is a current target for bioengineering the matrix and signaling factors. Herein, we present methods for studying six types of mammalian stem cells, m- mary, neural, mesenchymal, endothelial, dendritic, and muscle. 220 pp. Englisch.

Seller Inventory # 9781607610625

Bibliographic Details

• Title: Protocols for Adult Stem Cells
• Publisher: Humana Press Apr 2010
• Publication Date: 2010
• Language: English
• ISBN 10: 1607610620
• ISBN 13: 9781607610625
• Binding: Buch
• Condition: Neu
• Dimensions: 260W x 183H x 19D millimeters 260 millimeters width by 183 millimeters height by 19 millimeters depth
• Weight: 670 grams

About this title

Synopsis

Although embryonic stem cells currently enjoy the public limelight and show great pr- ise for cell based medical therapies, it is the adult stem cells which are responsible for the body’s natural ability to fght disease, heal and recover, or fail and succumb to various maladies. The study of mammalian adult stem cells has surged recently, most likely from a maturation of stem cell studies in the classical developmental model organisms and in hematopoeisis. All the tissues of the body examined so far are generated and regenerated from stem cells, it has been an important frst step to adapt or devise new methods to identify and obtain these cells in quantity and purity for further study. Culture techniques have been optimized for managing the growth and differentiation of stem cells in vitro; as some stem cells are pluripotent, often the method is to guide the fate of such cells among the possible differentiation fates. Much of this work, and that in the classical model org- isms, has helped defne the aspects of the stem cell environment or niche that are crucial for both growth and differentiation, and these studies have moved in vivo at increasingly higher resolution. Importantly, the in vivo niche is a current target for bioengineering the matrix and signaling factors. Herein, we present methods for studying six types of mammalian stem cells, m- mary, neural, mesenchymal, endothelial, dendritic, and muscle.

About the Author

Irina M. Conboy University of California, Berkeley, CA
David V. Schaffer University of California, Berkeley, CA
Mary Helen Barcellos-Hoff Lawrence Berkeley National Laboratory, Berkeley, CA
Song Li University of California, Berkeley, CA