The Pten Family

Charis Eng

ISBN 10: 162182344X / ISBN 13: 9781621823445

Published by Cold Spring Harbor Laboratory Press Jan 2020, 2020

About this Item

Neuware - Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of PTEN biology and its roles in human diseases. The contributors discuss the structural characteristics of PTEN; its functions at the plasma membrane as well as in the cytoplasm and nucleus; the mutations, interacting partners, and posttranslational modifications that affect its expression levels, subcellular localization, and enzymatic activity; and how this activity ultimately leads to changes in cell growth, migration, and morphology, as well as in gene expression, chromatin dynamics, and the maintenance of genomic stability. A historical perspective that covers the initial discovery and subsequent characterization of PTEN is also included.

Seller Inventory # 9781621823445

Bibliographic Details

• Title: The Pten Family
• Publisher: Cold Spring Harbor Laboratory Press Jan 2020
• Publication Date: 2020
• Language: English
• ISBN 10: 162182344X
• ISBN 13: 9781621823445
• Binding: Buch
• Condition: Neu
• Dimensions: 260W x 180H x 26D millimeters 260 millimeters width by 180 millimeters height by 26 millimeters depth
• Weight: 885 grams

About this title

Synopsis

The PTEN protein is a phosphatase that plays important roles as a tumor suppressor by negatively regulating the PI3K/Akt signaling pathway that controls cell proliferation and survival. Impaired PTEN function leads to unrestrained downstream signaling and, in turn, uncontrolled cell growth and cancer. PTEN also has other roles: Recent work has implicated it in a variety of additional biological processes, including control of DNA replication and repair, and in disparate pathological conditions (e.g., autism).

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of PTEN biology and its roles in human diseases. The contributors discuss the structural characteristics of PTEN; its functions at the plasma membrane as well as in the cytoplasm and nucleus; the mutations, interacting partners, and posttranslational modifications that affect its expression levels, subcellular localization, and enzymatic activity; and how this activity ultimately leads to changes in cell growth, migration, and morphology, as well as in gene expression, chromatin dynamics, and the maintenance of genomic stability. A historical perspective that covers the initial discovery and subsequent characterization of PTEN is also included.

In addition, the authors discuss the loss of PTEN function in various cancers, as well as in immune, metabolic, and neurological disorders (e.g., autoimmunity, type 2 diabetes, and autism), and consider how this knowledge can be exploited for diagnostic and therapeutic purposes. This volume is therefore essential reading for all cell and molecular biologists, cancer biologists, and pharmacologists interested in PTEN's remarkable biological complexity and importance in human health.

About the Author

Joanne Ngeow is with the National Cancer Centre Singapore. Charis Eng is with the Genomic Medicine Institute, Lerner Research Institute. Vuk Stambolic is with the Princess Margaret Cancer Centre.