QSAR Based Design & Synthesis | Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives

Priyal Jain (u. a.)

ISBN 10: 3846586021 / ISBN 13: 9783846586020

Published by LAP LAMBERT Academic Publishing, 2012

About this Item

QSAR Based Design & Synthesis | Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives | Priyal Jain (u. a.) | Taschenbuch | 76 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783846586020 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.

Seller Inventory # 106635285

Bibliographic Details

• Title: QSAR Based Design & Synthesis | Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3846586021
• ISBN 13: 9783846586020
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 5D millimeters 220 millimeters width by 150 millimeters height by 5 millimeters depth
• Weight: 131 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity.

About the Author

Priyal Jain Asst. Prof Sagar Institute of Research and Technology-Pharmacy, Bypass Road, Bhopal-462036 (M.P), India. He has devoted their work to develop different 3D & 2D QSAR models for drug design.