3D QSAR in Drug Design: Volume 1: Theory Methods and Applications (Three-Dimensional Quantitative Structure Activity Relationships, 1)

ISBN 10: 9072199146 / ISBN 13: 9789072199140

Published by ESCOM Science Publishers,The Netherlands, 1993

About this Item

Most items will be dispatched the same or the next working day. A copy that has been read, but is in excellent condition. Pages are intact and not marred by notes or highlighting. The spine remains undamaged.

Seller Inventory # rev5488893651

Bibliographic Details

• Title: 3D QSAR in Drug Design: Volume 1: Theory Methods and Applications (Three-Dimensional Quantitative Structure Activity Relationships, 1)
• Publisher: ESCOM Science Publishers,The Netherlands
• Publication Date: 1993
• Language: English
• ISBN 10: 9072199146
• ISBN 13: 9789072199140
• Binding: hardcover
• Condition: Very Good
• Weight: 1270.1 grams

About this title

Synopsis

Progress in medicinal chemistry and in drug design depends on our ability to understand the interactions of drugs with their biological targets. Classical QSAR studies describe biological activity in terms of physicochemical properties of substituents in certain positions of the drug molecules.
The purpose of this book is twofold: On the one hand, both the novice and the experienced user will be introduced to the theory and application of 3D QSAR analyses, and on the other, a comprehensive overview of the scope and limitations of these methods is given. The detailed discussion of the present state of the art should enable scientists to further develop and improve these powerful new tools.
The greater part of the book is dedicated to the theoretical background of 3D QSAR and to a discussion of CoMFA applications. In addition, various other 3D QSAR approaches and some CoMFA-related methods are described in detail. Thus, the book should be valuable for medicinal, agricultural and theoretical chemists, biochemists and biologists, as well as for other scientists interested in drug design. Its content, starting at a very elementary level and proceeding to the latest methodological results, the strengths and limitations of 3D QSAR approaches, makes the book also appropriate as a text for teaching and for graduate student courses.