Quantification of Structural Changes in the Brain

Klaus Hermann Fritzsche

ISBN 10: 3838118766 / ISBN 13: 9783838118765

Published by Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Nov 2015, 2015

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -Magnetic Resonance Imaging (MRI) and diffusion weighted MRI non-invasively deliver anatomical and even microstructural parameters of the living human brain with ever increasing resolution and detail. This book addresses current main challenges in detecting structural changes in the brain and diagnosing Alzheimer's Disease (AD) at early stages using imaging markers. An automated method for individual patient atrophy assessment on a macroscopic level and a Diffusion Tensor Imaging (DTI) based approach to fiber integrity assessment on a microscopic level are introduced. Diffusion phantoms are presented that allow the controlled investigation of quantification methods under PV conditions. A comprehensive set of in-vivo, in-vitro, and in-silico experiments are defined and applied to evaluate different existing and novel DTI- and Q-ball imaging based measures of brain integrity. The presented methods and findings improve the understanding, applicability, and diagnostic use of recently proposed imaging techniques and are an essential step as well towards clinical application of quantitative imaging as towards computer assisted early AD diagnosis. 248 pp. Englisch.

Seller Inventory # 9783838118765

Bibliographic Details

• Title: Quantification of Structural Changes in the Brain
• Publisher: Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Nov 2015
• Publication Date: 2015
• Language: English
• ISBN 10: 3838118766
• ISBN 13: 9783838118765
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 16D millimeters 220 millimeters width by 150 millimeters height by 16 millimeters depth
• Weight: 387 grams

About this title

Synopsis

Magnetic Resonance Imaging (MRI) and diffusion weighted MRI non-invasively deliver anatomical and even microstructural parameters of the living human brain with ever increasing resolution and detail. This book addresses current main challenges in detecting structural changes in the brain and diagnosing Alzheimer's Disease (AD) at early stages using imaging markers. An automated method for individual patient atrophy assessment on a macroscopic level and a Diffusion Tensor Imaging (DTI) based approach to fiber integrity assessment on a microscopic level are introduced. Diffusion phantoms are presented that allow the controlled investigation of quantification methods under PV conditions. A comprehensive set of in-vivo, in-vitro, and in-silico experiments are defined and applied to evaluate different existing and novel DTI- and Q-ball imaging based measures of brain integrity. The presented methods and findings improve the understanding, applicability, and diagnostic use of recently proposed imaging techniques and are an essential step as well towards clinical application of quantitative imaging as towards computer assisted early AD diagnosis.

About the Author

Klaus Hermann Fritzsche received his Diploma degree in Computer Science from the University of Karlsruhe, Germany, and completed the MSc program at the Federal University of Santa Catarina, Brazil, in 2006. He prepared his PhD-thesis at the German Cancer Research Center and the faculty of computer science at the University of Heidelberg.