Quantitative Perfusion MRI: Techniques, Applications and Practical Considerations (Volume 11) (Advances in Magnetic Resonance Technology and Applications, Volume 11)

Quantitative Perfusion MRI: Techniques, Applications, and Practical Considerations, Volume 11 clearly and carefully explains the basic theory and MRI techniques for quantifying perfusion non-invasively in deep tissue, covering all aspects of perfusion imaging, from acquisition requirements to selection of contrast agents and appropriate pharmacokinetic models and for reliable quantification in different diseases and tissue types. Specifically, this book enables the reader to understand what microvascular functional parameters can be measured with perfusion MRI, learn the basic techniques to measure perfusion in different organs, apply the appropriate perfusion MRI technique to the organ of interest, and much more.

This complete reference on quantitative perfusion MRI is highly suitable for both early and experienced researchers, graduate students and clinicians wishing to understand how quantitative perfusion MRI can apply to their application area of interest.

• Provides a one-stop resource for students and early and experienced researchers on all aspects of quantitative perfusion MRI as written by experts in the field
• Explains basic theory and MRI techniques
• Presents a strong focus on the practical considerations that can make or break perfusion MRI
• Includes applications in oncology, cardiology, neurology and body imaging

Prof. H.-L.M. Cheng is Full Professor at the University of Toronto in the Institute of Biomedical Engineering and the Edward S. Rogers Sr. Department of Electrical & Computer Engineering. She earned her B.Sc. and M.Sc. in Electrical & Computer Engineering at the University of Calgary and worked in industry on real-time synthetic aperture radar surveillance before completing her Ph.D. in Medical Biophysics at the University of Toronto on her thesis “MRI monitoring of focused ultrasound thermal ablation”. Her research in quantitative MRI methodologies expanded over the next decade at the Hospital for Sick Children, where she developed protocols for clinical research in parallel to forging the first MRI applications in tissue engineering and designing novel MRI contrast agents. In 2014, she joined the Faculty of Engineering at the University of Toronto and the Ted Rogers Centre for Heart Research. Her current research is focused on new contrast agent design and rapid, quantitative MRI methodologies for physiological, cellular, and molecular imaging, with an emphasis on early detection of heart failure and MRI-guided tissue regenerative therapies.

Prof. dr. G.J. (Gustav) Strijkers is Full Professor (Preclinical and Translational MRI) at the University of Amsterdam (UvA) and Adjunct Professor at Mount Sinai, New York. He earned his PhD at the Eindhoven University of Technology (TUE) with the title Magnetic Nanostructures and was a post-doctoral fellow at John Hopkins University, Baltimore. He served as assistant professor and associate professor at TUE and at UvA. He was a reviewer for several international journals and funding agencies and a member of scientific associations. Currently, his group uses a translational approach for the development of novel MRI sequences for improved diagnostics of disease and therapy monitoring. Novel preclinical protocols for high field MRI are initially developed in mouse and rat models. The most promising protocols are then translated for human clinical MRI. He established research programs on the development of comprehensive accelerated MRI protocols which provide valuable readouts in preclinical studies on the development and treatment of cardiovascular diseases, the application of traditional and novel nano particulate contrast agents, the improvement of imaging speed in MRI by the use of parallel imaging and novel mathematical imaging acceleration techniques, the use of multi-contrast MRI for the comprehensive and real-time evaluation of cancer therapy, and the development of diffusion-MRI to assess heart and skeletal muscle architecture and structural integrity in health and disease.