REDOX PROTEOMICS & BIOINFORMATICS : IDENTIFICATION OF OXIDIZED PROTEINS AND THEIR PHARMACOLOGICAL MODULATION: INSIGHTS INTO OXIDATIVE STRESS IN AGE-RELATED COGNITIVE IMPAIRMENT

Language: English

Published by LAP LAMBERT Academic Publishing, 2009

3838303865 / 9783838303864

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - The studies in this book demonstrated that increased oxidative stress in brain play a significant role in age-related cognitive impairment. Moreover, such increased oxidative stress leads to specific protein oxidation in the brain of cognitive impaired subject, thereby leading to cognitive function impairment. Moreover, the functional alterations of the proteins identified by proteomics in this book may leads to impaired metabolism, decline antioxidant system, and damaged synaptic communication. Ultimately, impairment of these processes lead to neuronal damages and cognitive decline. This book also show that several of the up- regulated and oxidized proteins in the brains of normal aging mice identified are known to be oxidized in neurodegenerative diseases as well, suggesting that the expression levels of certain proteins may increase as a compensatory response to oxidative stress. This compensation would allow for the maintenance of proper molecular functions in normal aging brains and protection against neurodegeneration.…

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Title
REDOX PROTEOMICS & BIOINFORMATICS : IDENTIFICATION OF OXIDIZED PROTEINS AND THEIR PHARMACOLOGICAL MODULATION: INSIGHTS INTO OXIDATIVE STRESS IN AGE-RELATED COGNITIVE IMPAIRMENT
Author
H. Fai Poon
Publisher
LAP LAMBERT Academic Publishing
Publication year
2009
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3838303865
ISBN 13
9783838303864
Item weight
512 grams
Dimensions
220x150x21 mm

AHA-BUCH GmbH

Einbeck, Germany

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