REDOX PROTEOMICS & BIOINFORMATICS | IDENTIFICATION OF OXIDIZED PROTEINS AND THEIR PHARMACOLOGICAL MODULATION: INSIGHTS INTO OXIDATIVE STRESS IN AGE-RELATED COGNITIVE IMPAIRMENT

Publisher

LAP LAMBERT Academic Publishing

Publication Date

2009

Language

English

ISBN 10

3838303865

ISBN 13

9783838303864

Binding

Taschenbuch

Condition

Neu

Dimensions

Weight

512 grams

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Synopsis

The studies in this book demonstrated that increased oxidative stress in brain play a significant role in age-related cognitive impairment. Moreover, such increased oxidative stress leads to specific protein oxidation in the brain of cognitive impaired subject, thereby leading to cognitive function impairment. Moreover, the functional alterations of the proteins identified by proteomics in this book may leads to impaired metabolism, decline antioxidant system, and damaged synaptic communication. Ultimately, impairment of these processes lead to neuronal damages and cognitive decline. This book also show that several of the up- regulated and oxidized proteins in the brains of normal aging mice identified are known to be oxidized in neurodegenerative diseases as well, suggesting that the expression levels of certain proteins may increase as a compensatory response to oxidative stress. This compensation would allow for the maintenance of proper molecular functions in normal aging brains and protection against neurodegeneration.

About the Author

Dr. H. Fai Poon completed his Ph.D. in Biological Chemistry (Proteomics Concentration) at University of Kentucky. He is one of the frontiers in Redox proteomics. He is currently the associate Editor for Journal of Chemistry, Biochemistry and Molecular Biology, and Journal of Biometrics and Bioinformatics.

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