ROLE OF RAGE AS AN AMPHOTERIN RECEPTOR: FROM DEVELOPMENT TO DISEASE

Henri Huttunen

ISBN 10: 3838323475 / ISBN 13: 9783838323473

Published by Lap Lambert Acad. Publ., 2009

About this Item

64 pages. 8.70x5.94x0.31 inches. In Stock. Seller Inventory # __3838323475

Bibliographic Details

Title: ROLE OF RAGE AS AN AMPHOTERIN RECEPTOR: FROM...

Publisher: Lap Lambert Acad. Publ.

Publication Date: 2009

Binding: Paperback

Condition: Brand New

About this title

Synopsis:

Cell migration plays a vital role in many physiological processes, such as embryonic development and immunological defense, but also in pathological processes, such as tumor cell invasion. Amphoterin, also known as High-Mobility Group-Box protein 1 (HMGB1), is highly expressed in immature and malignant cells. Although it lacks a classical secretion signal, amphoterin is released from cells to regulate neurite outgrowth, cell migration and differentiation. Many extracellular functions of amphoterin are mediated by one of its cell surface receptors Receptor for Advanced Glycation End products (RAGE), a multiligand receptor belonging to the immunoglobulin superfamily. This thesis concentrates on identifying molecular mechanisms through which RAGE mediates effects of extracellular amphoterin on cells. The results suggest that amphoterin and RAGE serve as a ligand-receptor pair having important roles in the regulation of neuronal process growth, survival and differentiation, and in the regulation of tumor cell invasiveness.

About the Author:

Henri Huttunen earned his Ph.D. in biochemistry from University of Helsinki. His research focuses in molecular mechanisms underlying the generation and loss of connectivity of neurons in the brain. He has studied molecules regulating cell migration in the developing brain and more recently mechanisms of neurodegeneration in Alzheimer's disease.