RP-HPLC Method Development and Validation for Palbociclib and Letrozole | Analytical Method Development

Yuvraj Dange (u. a.)

ISBN 10: 6202523239 / ISBN 13: 9786202523233

Published by LAP LAMBERT Academic Publishing, 2020

About this Item

RP-HPLC Method Development and Validation for Palbociclib and Letrozole | Analytical Method Development | Yuvraj Dange (u. a.) | Taschenbuch | 104 S. | Englisch | 2020 | LAP LAMBERT Academic Publishing | EAN 9786202523233 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 118335816

Bibliographic Details

• Title: RP-HPLC Method Development and Validation for Palbociclib and Letrozole | Analytical Method Development
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2020
• Language: English
• ISBN 10: 6202523239
• ISBN 13: 9786202523233
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 7D millimeters 220 millimeters width by 150 millimeters height by 7 millimeters depth
• Weight: 173 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Current aim is to develop a simple, rapid, accurate, economic, precise stability indicating assay method for the simultaneous estimation of Palbociclib and Letrozole in pure drug and dosage form. For these purpose choices of a common solvent was essential so various solvent ranges including methanol, ethanol, acetonitrile,and phosphate buffer and various concentrations ranges of various buffers were analyzed. Few methods have been reported on above drugs by using water as common solvent which is the cheapest; therefore finally the common solvent for the above drugs was chosen as sodium Dihydrogen phosphate pH 5.5 (0.05 mm) which is more cheaper than any organic solvent. Palbociclib and Letrozole show maximum absorbance at 220 and 240 nm respectively. Both drugs obey Beer Lambert’s law in the concentration range of 2-10 μg/ml and 40-140 μg/ml for Palbociclib and Letrozole respectively.The RP-HPLC method was developed using Intersil ODS-C8, (4.6mm x 250mm; 5μm) column, at ambient temperature using mobile phase Methanol: Acetonitrile: 0.05mM sodium dihydrogen phosphate buffer (pH adjusted to 5.5 with NaOH) in10:10:80 v/v proportion found to give sharp, well defined peaks.